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The team treated 11 Amish patients with the double mutation.
The single mutation, however, led to increased logevity.
Amish people with the mutation has very low levels of PAI-1, which is known to be related to aging in animals but its effect in humans has been less clear.'The findings astonished us because of the consistency of the anti-aging benefits across multiple body systems,' said Dr Douglas Vaughan, the lead author of the paper who has been studying PAI-1 for almost 30 years.
'For the first time we are seeing a molecular marker of aging (telomere length), a metabolic marker of aging (fasting insulin levels) and a cardiovascular marker of aging (blood pressure and blood vessel stiffness) all tracking in the same direction in that these individuals were generally protected from age-related changes,' Dr Vaughan said.'That played out in them having a longer lifespan.
A measure that reflects vascular age was also lower - indicative of retained flexibility in blood vessels in the carriers of the mutation - than those who don't have the mutation.
They lived more than ten per cent longer and had 10 per cent longer telomeres (a protective cap at the end of our chromosomes that is a biological marker of aging) than Amish family members who don't have the mutation.
The drug has passed basic safety trials and is now being tested in phase 2 trials in Japan on how well it works on insulin sensitivity in people with type 2 diabetes and obesity.The celebration was also part of a farewell picnic for those sentenced in hair and beard cutting scandal earlier in 2013One group of reformers rejected the concept of infant baptism, and thus became known as 'Anabaptists.' The Anabaptists believed that only adults who has confessed their faith should remain separate fro the larger society.Anabaptist groups were severely persecuted throughout Europe, and thousands were put to death as heretics by Catholics and Protestants.'It's a desirable form of longevity.'Researchers studied 177 members of the Berne Amish community in Indiana, and found 43 who had one mutant copy of the gene, SERPINE1.Amish people with this gene mutation were also significantly less likely to get diabetes, and had 30 per cent lower fasting insulin levels, and more efficient metabolisms.